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Monday, May 11, 2020 | History

2 edition of Opioids in the hippocampus found in the catalog.

Opioids in the hippocampus

Jacqueline F McGinty

Opioids in the hippocampus

by Jacqueline F McGinty

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  • 9 Currently reading

Published by U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse, Supt. of Docs., U.S. G.P.O., distributor] in Rockville, MD, [Washington, D.C.? .
Written in English

    Subjects:
  • Opioids -- Receptors,
  • Hippocampus (Brain)

  • Edition Notes

    Statementeditors, Jacqueline F. McGinty, David P. Friedman
    SeriesNIDA research monograph -- 82, DHHS publication -- no. (ADM) 88-1568
    ContributionsFriedman, David P, National Institute on Drug Abuse
    The Physical Object
    Paginationx, 151 p. :
    Number of Pages151
    ID Numbers
    Open LibraryOL13610925M

    Using 5¬bromodeoxyuridine (BrdU) and Ki as mitotic markers at the end of the drug treatments, we found that both short- and long-term cocaine exposures significantly reduced cell proliferation in the dentate gyrus (DG) of the hippocampus. the hippocampus proper, and in the lower layers, which receive inputs from the hippocampus. Each of these cells lays a grid-like pattern of firing on top of every environment the animal encounters. The orientation and spacing of the grid varies in a The Hippocampus Book.

    The first in a 5-part series, offers an understanding of the brain, how the reward center works, and what happens in the brain when a person uses cocaine, opioids (heroin), or marijuana. The objective of the presentation is to inform students (high school) how 3 drugs of abuse (cocaine, opiates, marijuana) actually work in the brain.   Chronic pain patients exhibit learning and emotional changes not often reversed by painkillers, including deficits in working memory, emotional decision-making, and classical conditioning tasks, as well as elevated anxiety and depression. Despite this knowledge, the role of the hippocampus, a crucial limbic area involved in learning and memory, in chronic pain has been largely unexplored. Now A.

    Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and opioid receptors are ~40% identical to somatostatin receptors (SSTRs). Opioid receptors are distributed widely in the brain, in the spinal cord, on peripheral neurons, and digestive tract. Over time, this may cause the hippocampus to become smaller and less effective, further reducing memory abilities. Individuals Affected by Opiate Abuse and Dependence Suffer from Memory Problems Researchers have carefully studied the short and long term .


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Opioids in the hippocampus by Jacqueline F McGinty Download PDF EPUB FB2

Physiological Opioids in the hippocampus book. Finally, the role of the hippocampus in the myriad of opioid- and opiate-modulated behavioral effects re-quires much study, because there is still so much we do not know.

The first 10 years of study of opioids in the hippocampus have pro-duced a solid base of knowledge and any number of interesting leads for the Size: 1MB. Hippocampus "This is, in short, an outstanding scholarly book that deserves to be read by anyone with a deep interest in neuroscience or memory and will no doubt be frequently referred to in the future."--PsycCRITIQUES "An all-in-one resource of information about the hippocampus, this book is 4/4(8).

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Opioid Modulates Adult Neural Progenitors Survival and Apoptosis. After being generated by neural stem cells in the DG of hippocampus, a large portion of these progenitors die within a few days following their birth [].It is reasonable to assume that the neural precursors which fail to differentiate into functional immature neurons would go through by: 9.

During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the factors that regulate proliferation and fate determination of adult neural stem/progenitor cells, including addictive drugs such as opioid.

Here, we review the most recent works on opiate drugs&#x; effect on different developmental Cited by: 9. Organization and Content of the Book 6 Chapter 2 Historical Perspective: Proposed Functions, Biological Characteristics, and Neurobiological Models of the Hippocampus 9 Per Andersen, Richard Morris, David Amaral, Tim Bliss, and John O'Keefe Overview 9 The Dawn of Hippocampal Studies 9 Λ Famous Dispute About the Significance.

Opioids, to varying degrees, may antagonize N-methyl-D-aspartate (NMDA) receptors, activating the descending serotonin and noradrenaline pain path-ways from the brain stem. Stimulation of these same NMDA receptors may result in neuropathic pain and the development of tolerance (9).

The location of endogenous opioids or endor. This is how opioids brew a potent and deadly addiction in the brain. Societies have coveted the euphoria and pain relief provided by opioids since Ancient Sumerians referred to. Of the 14 patients, 13 tested positive for opioids or had a documented history of opioid use.

MRI scans revealed that the hippocampus, which is. The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists.

The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading Long known to be important for memory, it has been a prime focus of neuroscience research for many years/5.

Prescription and illegal opioids are commonly abused because they are so addictive. Opioid medications bind to the areas of the brain that control.

Opiates are among the most commonly abused illegal drugs in the United States (1, 2).Several reports suggest that chronic exposure to opiates, such as morphine and heroin, can result in cognitive deficits (3–5).For example, heroin users have poorer performance on attention, verbal fluency, and memory tasks than controls (), and rats chronically exposed to morphine show impaired Cited by: The hippocampus (via Latin from Greek ἱππόκαμπος, "seahorse") is a major component of the brain of humans and other and other mammals have two hippocampi, one in each side of the hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that MeSH: D The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe.

Long known to be important for memory, it has been a prime focus of neuroscience. Indeed, in the hippocampus of these animals, the opioids had predominantly inhibitory effects which were potentiated, not antagonized, by naloxone. It is concluded that the low concentration of opiate receptors in the rat hippocampus renders neurones within this structure sensitive to a variety of non- Cited by: We tested the hypothesis that positive affect would be associated with release of endogenous opioids, especially in regions like the amygdala, orbitofrontal cortex, and higher level sensory regions, which show the greatest density of opioid receptors (Lewis et al., ).Induction of positive emotion using a combination of validated methods lead to reductions in [11 C]DPN binding, consistent Cited by: The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe.

Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists 5/5(2).

Title:Effects of Vitamin A Deficiency and Opioids on Parvalbumin + Interneurons in the Hippocampus of the HIV-1 Transgenic Rat VOLUME: 10 ISSUE: 5 Author(s):Ming Guo, Joseph Bryant, Shireen Sultana, Odell Jones and Walter Royal III Affiliation:University of Maryland School of Medicine, South Paca Street, 3rd Floor, Baltimore, MDUSA.

Hippocampus, region of the brain that is associated primarily with name hippocampus is derived from the Greek hippokampus (hippos, meaning “horse,” and kampos, meaning “sea monster”), since the structure’s shape resembles that of a sea hippocampus, which is located in the inner (medial) region of the temporal lobe, forms part of the limbic system, which is.

The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists working on hippocampal anatomy, physiology, and function.4/5(16).All drugs of abuse, from nicotine to heroin, cause a particularly powerful surge of dopamine in the nucleus accumbens.

The likelihood that the use of a drug or participation in a rewarding activity will lead to addiction is directly linked to the speed with which it promotes dopamine release, the intensity of that release, and the reliability of that release.The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists working on hippocampal anatomy, physiology, and function.

This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how.